Botulinum toxin is a powerful neurotoxin derived from the bacterium Clostridium botulinum, capable of temporarily halting muscle movement. It has been safely used in medical and aesthetic fields for many years, prominently emerging as an effective method for reducing wrinkles caused by facial expression muscles.
Aging leads to lines in areas like the forehead, between the eyebrows, around the eyes (crow's feet), nose, and above the lips, caused by the continuous movement of underlying facial expression muscles. Botulinum toxin applications temporarily paralyze these muscles, resulting in a smoother and younger-looking skin.
Botulinum toxin is extensively used not only for cosmetic purposes but also for medical needs. Its primary areas of application are as follows:
• Reduction of dynamic wrinkles
• Excessive sweating (hyperhidrosis)
• Teeth grinding (bruxism)
• Strabismus treatment
• Alleviation of migraine pain
• Balancing asymmetries after facial paralysis
Botulinum toxin application is performed by experienced specialists using the injection method. The toxin is diluted with a sterile serum and injected into target muscles using fine needles. In applications close to the skin surface like excessive sweating, the injection is made directly into the dermis.
The procedure generally takes a few minutes, and patients can return to their daily lives shortly afterward. If necessary, a local anesthetic cream can be applied beforehand to minimize pain sensation.
The effects usually start becoming visible within 3 to 5 days following the application. Maximum effect is reached within 10 to 14 days. While the duration varies from person to person, it typically lasts 3 to 4 months. For some individuals, this period may extend up to 6 months. Regular applications cause the facial expression muscles to weaken over time, thus reducing the depth of wrinkles.
For aesthetic purposes, it can be safely administered from the late 20s onwards, while for issues like excessive sweating, it is suitable for individuals aged 18 and over. An evaluation by a specialist physician before the application is crucial to prevent potential risks.
Botulinum toxin is not suitable for individuals with certain neurological and muscular diseases. The procedure should especially be avoided in individuals with the following conditions:
• Myasthenia Gravis
• Lambert-Eaton Syndrome
• Diseases characterized by muscle weakness such as ALS
In individuals in this group, the potential harms of botulinum toxin can reach serious levels; hence decisions must be made under physician supervision.
Although generally considered safe, some side effects can occur as with any medical procedure. These are mostly mild and temporary:
• Redness, bruising, or swelling at the injection site: Generally resolves within a few days.
• Temporary muscle weakness and eyelid droop: May occur if the toxin spreads to non-targeted muscles.
• Headache and flu-like symptoms: May occur post-application in some patients.
• Allergic reactions: Rarely, itching, rash, or edema at injection site.
• Difficulty swallowing or speaking: Can temporarily occur especially in neck applications.
All these effects are generally short-lived. If an unexpected situation arises, a healthcare professional should be consulted without delay.
The application of botulinum toxin is typically a very comfortable procedure, causing minimal discomfort. The needles used are extremely thin and the injection is performed only onto the skin surface. Therefore, patients usually describe only a slight pricking or needle sensation. For those with sensitive skin or who wish to enhance comfort, topical anesthetic creams can be used before the procedure to numb the area. This ensures that the patient feels almost nothing during the procedure. In general, botulinum toxin injection is a fast and tolerable procedure that can be easily administered without interrupting patients’ daily lives.
To optimize results and minimize the risk of side effects following botulinum toxin injection, some important rules should be observed. The treated area should not be touched, massaged, or rubbed for at least 4 hours following the procedure. During this time, patients are advised to keep their head upright and avoid lying down to prevent the toxin from inadvertently spreading to undesired areas.
On the day of the procedure, heavy exercises, lying face down, hot environments like baths or saunas, and steam baths should be avoided. Sweating can affect the distribution of the toxin at the application site. Also, alcohol consumption and the use of blood-thinning medications (aspirin, ibuprofen, etc.) should be avoided for a few days post-procedure, as they can increase the risk of bruising.
The effect of botulinum toxin injection does not begin immediately. Initial effects are typically noticeable within 3 to 5 days post-procedure. During this period, the gradual loss of movement capability in the facial expression muscles is observed. Maximum therapeutic effect is usually observed within 10 to 14 days. It is recommended to wait at least 2 weeks for the results to fully emerge.
At the end of this period, expression lines significantly soften, and the skin gains a smoother and younger appearance. If the desired effect is not achieved, touch-up injections may be administered under doctor supervision. Although the duration of effect varies among individuals, it usually lasts between 3 to 6 months.
Botulinum toxin treatment is generally a safe method when applied in appropriate doses by a specialist physician. The toxin has been successfully used worldwide for both medical and cosmetic purposes on millions of patients for years. As with any medical procedure, there are some risks and considerations associated with this application.
In particular, individuals with neuromuscular diseases (such as myasthenia gravis) may experience serious complications from botulinum toxin. Therefore, a comprehensive health history assessment is essential before the procedure. It is also not recommended for pregnant or breastfeeding women due to insufficient clinical data.
Apart from that, when applied professionally, no serious problem is encountered aside from minor side effects like mild redness, bruising, or temporary headaches post-procedure. When performed within safe protocols, botulinum toxin application is both an effective and low-risk cosmetic intervention.