Ozone therapy is a method that has been mentioned more frequently in different fields of health in recent years and is considered among complementary practices. This approach, which is based on the application of medical ozone gas to the body with specific techniques, aims to support the body’s natural balance and healing processes. Due to its possible effects on the immune system, circulation and cellular oxygenation, ozone therapy is a subject of interest; it can be performed with different application methods and it is important that the process is planned under specialist supervision.
Ozone therapy is a complementary treatment approach based on the principle of administering ozone gas, which is used for medical purposes, to the body via specific methods.
Ozone is a gas composed of three oxygen atoms (O₃). In medical use, it is produced via special devices and applied in a controlled manner. Rather than treating a disease directly, this application aims to support the body’s natural healing processes.
Ozone therapy is anticipated to have effects such as supporting the immune system, improving circulation and increasing cellular oxygenation. These effects are associated with the controlled oxidative stress response that ozone induces in the body. In this way, the body may activate its own defense and repair mechanisms. From this perspective, the answer to the question “what is ozone therapy used for” can be considered within the scope of supporting the immune system, circulation and cellular functioning.
Ozone therapy is a process that can be applied via different methods depending on the person’s health status and needs. Medical ozone gas can be administered into the body alone through specific techniques or mixed with blood in some applications. The method of application is determined after an individual assessment and the process is planned under specialist supervision.
The most commonly used ozone therapy methods can be listed as follows:
In this method, a certain amount of blood is drawn from the person, mixed with medical ozone gas and then re-administered into the body intravenously. It is one of the frequently preferred applications and is generally considered for overall supportive purposes.
Compared with other treatment methods, a smaller amount of blood is taken, mixed with ozone gas and injected into a muscular area. This method may be preferred in some cases for its supportive effects on the immune system.
Ozone gas is administered into the body in a controlled manner via the intestinal route. In this method, absorption of the gas takes place through the intestinal mucosa, and in some cases it may be considered as an alternative application method.
These are methods that are applied directly to a specific area. They can be performed as applications targeting the joints, muscles or skin surface. Such applications may be preferred as a supportive approach for the relevant area.
Water or oils enriched with ozone gas can be used in some superficial applications. These methods are generally among the supportive applications targeting the skin surface.
In ozone therapy, the duration and number of sessions vary from person to person. Generally:
Sessions last on average 20–40 minutes.
The treatment plan can be organized as courses consisting of several sessions.
Session frequency is adjusted according to individual needs.
The ozone therapy application methods and process may differ from person to person. Therefore, the individual’s health status should be evaluated in detail before the application. Ozone therapy should not be considered as a stand-alone treatment method but as a complementary and supportive approach.
Ozone therapy can be considered as a supportive approach in some diseases. It may especially be considered as a complementary application in the following conditions:
Diabetic Foot Ulcers and Non‑healing Chronic Wounds
Diabetic foot ulcers and chronic wounds that do not heal for a long time are conditions in which the treatment process is difficult due to poor circulation and a high risk of infection. It is anticipated that ozone therapy may contribute to increasing tissue oxygenation and supporting the healing process in such wounds.
Fibromyalgia and Chronic Fatigue Syndrome
Fibromyalgia and chronic fatigue syndrome are characterized by widespread muscle pain, malaise and a decrease in quality of life. Ozone therapy may support energy metabolism in these diseases.
Pain Due to Lumbar and Cervical Disc Herniation
Pain resulting from lumbar and cervical disc herniation may adversely affect daily life. Ozone applications are considered to potentially help reduce inflammation in the relevant area and support pain control.
Circulatory Disorders and Vascular Diseases
Problems related to the circulatory system may cause tissues to receive insufficient oxygen. Ozone therapy may contribute to increasing the transport of oxygen to cells by supporting blood circulation. Suitability may differ for each individual, and specialist assessment is required before application.
Ozone therapy is thought to have various effects that may support the body’s natural functioning in some situations. These effects are associated with the biological responses that ozone gas induces at the cellular level.
The possible benefits of ozone therapy can be listed as follows:
It may support the immune system: It may contribute to the regulation of the body’s defense mechanisms and help increase resistance to infections.
It may help increase cellular oxygen utilization: By supporting cells to use oxygen more efficiently, it may contribute to general metabolic processes.
It may support the circulatory system: By supporting the regulation of blood circulation, it may improve oxygen delivery to tissues.
It may contribute to a feeling of increased energy levels: By supporting cellular energy production processes, it may help reduce the feeling of fatigue.
It may support the management of chronic pain: In some conditions related to the musculoskeletal system, it may be effective in pain management.
It may support skin health: By contributing to oxygenation of the skin tissue, it may help maintain a healthier appearance.
It may contribute to tissue healing processes: It may show supportive effects on healing mechanisms, especially in areas with poor circulation.
The effects of ozone therapy may vary from person to person.
When applied under appropriate conditions and under specialist supervision, ozone therapy is generally considered safe. However, as with every medical application, some individuals may experience mild and temporary side effects with ozone therapy.
Possible side effects of ozone therapy can be listed as follows:
Mild dizziness: May be felt for a short time after the application.
Feeling of fatigue: Temporary tiredness may occur after the session.
Sensitivity at the application site: Mild pain and tenderness may be observed in the injected area.
Temporary reactions: In rare cases, different responses may develop due to individual sensitivity.
Nausea or a feeling of discomfort: Especially after rectal application, some individuals may experience temporary gastrointestinal discomfort.
Temporary redness or swelling at the application site: Short‑term local reactions may occur in the injected area.
Rare hypersensitivity reactions: Unexpected responses may develop due to sensitivity; in such a case, the application should be discontinued.
These effects are generally mild and temporary; in most cases, they may resolve spontaneously. However, if an unexpected, severe or prolonged reaction develops, the application should be interrupted and a specialist physician should definitely be consulted. Before starting ozone therapy, evaluation of the individual’s health status by a physician is important in terms of minimizing possible risks.
Ozone therapy may not be suitable for every individual, and the person’s overall health status should be evaluated in detail before application. In particular, in some special situations, ozone therapy may not be recommended or may require careful planning. In this context,
In individuals who are pregnant,
In people with G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency,
In individuals with bleeding disorders
a comprehensive medical evaluation must be performed before ozone therapy is administered.
The duration of ozone therapy varies depending on the preferred method and the person’s needs. Generally, sessions are completed in an average of 20 to 40 minutes. The treatment plan and session duration are determined by the specialist following an individual assessment.
When performed for appropriate indications and under specialist supervision, it is considered safe. However, as with every medical application, assessing individual risks is important.
After ozone therapy, although this may vary depending on the area of application, short-term rest is generally recommended. Plenty of fluids should be consumed after the session, strenuous physical activities should be avoided, and the individual care plan recommended by the physician should be followed. Since the treatment process may differ for each individual, post‑treatment recommendations should be determined specifically for the person by the specialist.
Ozone therapy is not accepted as a stand‑alone method in the treatment of cancer diseases. In some cases, based on a physician’s evaluation, it may be considered as a supportive and complementary approach. However, the main approach in cancer treatment consists of methods whose effectiveness has been scientifically proven, and the entire process must be carried out under the supervision of a specialist physician.
The time it takes to feel the effects of ozone therapy may vary from person to person. The process may differ depending on the purpose of application, general health status and treatment plan. Therefore, the duration of effect should be considered within the scope of individual assessment.